Severe blood dyscrasias. Progressive renal disease. Severe hepatic disorder, SLE. History of necrotising enterocolitis, pulmonary fibrosis, exfoliative dermatitis, bone marrow aplasia.
Contraindicated during pregnancy and lactation.
Contraindicated to paediatrics.
Caution
:
Periodically monitor blood counts and urinary protein. Women of child bearing age should use effective contraception during and at least six months after treatment. Renal and hepatic dysfunction. History of bone marrow depression.
