It provide protection from haematological, acute and cumulative nonhaematological side-effects associated with cancer chemo-therapeutic agents.
Contra Indication
:
Hypersensitivity to aminothiol compounds, patients with low blood pressure or in dehydration, patients with renal or hepatic impairment
Contraindicated during pregnancy and lactation.
Contraindicated to paediatrics.
Contraindicated to elderly.
Caution
:
Patients should be well hydrated and kept supine during amifostine infusion. the dose of amifostine should be administered in 15 minutes. Antiemetics should be adminisstered before and during the infusion of amifostine. Antihypertensive drug should be stopped twenty four hour before the infusion of amifostine.
Side Effect
:
Hypertension. Transient and rapidly reversible loss of consciousness. Nausea, vomiting, flushing or feeling of warmth, chills, dizziness, somnolence, sneezing and hiccups.
